The Rich Inner Life of a Thrombus – “Next Generation” Analysis of Platelet Activity During Thrombus Formation in Vivo

Niklas Boknäs, M.D., M.Sc., Ph.D.
Linköping University, Department of Hematology and Department of Biomedical and Clinical Sciences
Linköping, Sweden

Pia Larsson, Ph.D.
Australian Centre for Blood Diseases, Monash University
Melbourne, Australia

Fluorescence microscopy has proven to provide valuable insights to the structural composition of a developing thrombus. There is a need for a more detailed characterization of the complex and highly dynamic processes that shape thrombus architecture. Pia Larsson, Ph.D., and Niklas Boknäs, M.D., discuss a study that is aimed at developing experimental models and analytical tools to provide an automatized, quantitative analysis of the movements and activation states of platelets during in vivo thrombus formation. The presentation also showcases the need for refinement of our conceptual understanding of the hemostatic response to injury.